Another study showed that saffron supplementation for 12 months could help preserve some retinal function parameters, with few side effects noted.
Some smaller studies have also observed:
improvement in contrast sensitivity
slight improvement in visual acuity
possible slowing of disease progression
although in limited samples.
Limitations of Scientific Evidence
Despite promising results, it is important to note that:
Studies often have few participants
The duration is relatively short
The results are modest
There are still no official guidelines recommending saffron as a standard therapy
Currently, the supplements with the most consolidated evidence remain those of the AREDS2 formula (lutein, zeaxanthin, vitamins, and minerals), while saffron is considered a potential nutritional support, still under study.
Can saffron replace medical therapies?
No. Saffron is not a cure for macular degeneration and should not replace:
eye exams
prescribed therapies
doctor-recommended supplements
It can only be considered as a nutritional supplement after consulting a doctor.
Safety and Dosage
In clinical studies, saffron was generally well tolerated at doses of around 20-30 mg per day.
Very high doses can cause side effects, so supplementation should always be evaluated by a healthcare professional.
Research suggests that saffron may play an interesting role as a nutritional support for retinal health thanks to its antioxidant and neuroprotective properties. However, scientific evidence is still limited, and larger, longer-term studies are needed to confirm its clinical efficacy.
For this reason, saffron can be considered a potential supplement, but not a therapy, for macular degeneration.
